Bicarbonate treatment of acidosis produces paradoxical acidosis in the brain
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منابع مشابه
Sodium bicarbonate for the treatment of lactic acidosis.
Lactic acidosis often challenges the intensivist and is associated with a strikingly high mortality. Treatment involves discerning and correcting its underlying cause, ensuring adequate oxygen delivery to tissues, reducing oxygen demand through sedation and mechanical ventilation, and (most controversially) attempting to alkalinize the blood with IV sodium bicarbonate. Here we review the litera...
متن کاملBicarbonate therapy and intracellular acidosis.
1. The correction of metabolic acidosis with sodium bicarbonate remains controversial. Experiments in vitro have suggested possible deleterious effects after alkalinization of the extracellular fluid. Disequilibrium of carbon dioxide and bicarbonate across cell membranes after alkali administration, leading to the phenomenon of 'paradoxical' intracellular acidosis, has been held responsible for...
متن کاملBicarbonate therapy in severe metabolic acidosis.
The utility of bicarbonate administration to patients with severe metabolic acidosis remains controversial. Chronic bicarbonate replacement is obviously indicated for patients who continue to lose bicarbonate in the ambulatory setting, particularly patients with renal tubular acidosis syndromes or diarrhea. In patients with acute lactic acidosis and ketoacidosis, lactate and ketone bodies can b...
متن کاملSodium bicarbonate controversy in lactic acidosis.
1 Barst RJ. Experience and reason [editorial]. Chest 2000; 117:2–5 2 Klings ES, Hill NS, Ieong MH, et al. Systemic sclerosisassociated pulmonary hypertension: shortand long-term effects of epoprostenol (prostacyclin). Arthritis Rheum 1999; 42:2638–2645 3 Klings ES, Ieong MH, Simms RW, et al. Long-term intravenous epoprostenol therapy for pulmonary hypertension associated with systemic sclerosis...
متن کاملTherapy of bicarbonate-losing renal tubular acidosis.
Donckerwolcke, R. A., van Stekelenburg, G. J., and Tiddens, H. A. (1970). Archives of Disease in Childhood, 45, 774. The therapy of bicarbonate-losing renal tubular acidosis. A 2-year-old-girl with severe bicarbonate-losing renal tubular acidosis was treated successively with bicarbonate, THAM, and two diuretics, hydrochlorothiazide and frusemide. Only with hydrochlorothiazide was adequate corr...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1073-b